时　　间：10月31日（周六）14:00—17:00

地　　点：勤园20-518

报告摘要：

Cardiac arrhythmias account for about 1 death in 10 in industrialized countries. Although cardiac arrhythmias have been studied for well over a century, their underlying mechanisms remain largely unknown. Over the years, several factors that favor arrhythmia initiation were established. Among them are ionic and dynamical heterogeneity, remodeling and fibrosis of cardiac tissue. In addition, a lot of attention was given to the arrhythmias which occur due to channelopathies which result in the long QT syndrome.

In my talk, I will present our studies of the role of these arrhythmogenic factors performed using various models developed in our group. In particular, I will address the possible role of large- and small-scale ionic heterogeneities found in the human heart on the onset and dynamics of ventricular arrhythmias. We show that they can lead to drift and can attract and anchor the rotors. Further, I discuss the role of fibrosis in the onset of cardiac arrhythmias. In particular, we study the attraction of the rotors to the fibrotic scar. We demonstrate that rotors indeed can be attracted by fibrotic scars via the process of dynamical reorganization of the excitation pattern, which we call dynamical anchoring. We illustrate this process using a patient-specific model of the heart. Finally, we have also studied arrhythmias which occur as a result of early afterdepolarizations (EADs) and their relation to the mechanisms of Torsades de Pointes (TdP).

报告人简介：

Alexander V. Panfilov，荷兰籍，生物物理学博士。曾执教于荷兰乌得勒支大学，2011—2021年任比利时根特大学物理与天文系教授，现为该校荣休教授、荷兰莱顿大学医学中心心内科教授。长期从事心脏电生理与心律失常的计算建模研究，在螺旋波动力学、解剖学精确心脏模型以及纤维化、早期后除极诱发心律失常的机制等方面取得了系统性成果。承担荷兰NWO、比利时FWO等多项科研项目，在Science、Circulation、Physical Review Letters等期刊发表论文230余篇，Google Scholar h指数57，指导博士论文14篇，并担任PLOS One等期刊编委。